FIGURE 1.

PDLLCL scaffold concept. The PDLLCL scaffold contains PE rods with high hydrophobicity to keep the channels patent during the 4-week implantation period before introduction of islets. Fibrin facilitates vascularization (pink substance in left picture). The scaffold is implanted subcutaneously 4 weeks before introduction of islets during which the foreign body response is dampened and vascularization is completed. Upon removal of the rods, the islets can be easily infused (right picture). PE, polyethylene.