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. 2020 May 7;8(1):e000262. doi: 10.1136/jitc-2019-000262

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Design for clinical trial to evaluate safety and immunogenicity of phosphopeptide-based vaccine in melanoma patients. Participants were eligible for all arms with stage IIIB-IV melanoma, with measurable disease, or after surgical resection. Eligibility for arm C was extended to stage II–IIIA patients, after surgical resection. The study was also opened to participants with other solid tumors, but only participants with melanoma enrolled. IFA, incomplete Freund’s adjuvant; PBMC, peripheral blood mononuclear cell; pIRS2, phosphopeptide from insulin receptor substrate 2; tet, tetanus helper peptide.