Skip to main content
. 2020 May 15;6(20):eaaz4988. doi: 10.1126/sciadv.aaz4988

Fig. 5. Stability study and oral glucose tolerance test.

Fig. 5

(A) Analytic HPLC traces of 1, 2, 3, and 5 before and after incubation with Pronase (0.1 mg/ml). (B) The serum stability of 1, 2, 3, and 5 was determined in 25% serum (v/v) at 37°C for 24 hours. (C and D) Pharmacodynamics of the GLP-1 mimic peptides in mice. A Single dose of peptides was intraperitoneally administered into mice 1 hour before the oral glucose tolerance test (OGTT) (2 g/kg glucose). (C) Blood glucose concentrations were monitored for up to 120 min after oral glucose challenge. (D) Average area under the curve (AUC) calculated from OGTT data. Results show mean ± SEM of six mice per treatment group; *P < 0.05 versus vehicle; t test.