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. 2020 May 15;6(20):eaaz9240. doi: 10.1126/sciadv.aaz9240

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 3 — (A) CXCR4 antagonism ability of the nanocomplex relative to AMD3100. Data were analyzed with unpaired t test (****P < 0.0001 versus PEI). (B) PD-L1 gene silence by the nanocomplex (100 nM siPD-L1) in vitro. (C) Expression of CRT on LLC cells treated with PBS, free PTX, PEI/siPD-L1, FX/siScr@HP, FX/siPD-L1, and FX/siPD-L1@HP (100 nM PTX and 100 nM siPD-L1). (D) Flow cytometry assay of CRT expression on LLC cells after different treatments. Expression of (E) CD86 and (F) CD40 of CD11c⁺ BMDCs after coculturing with LLC cells with different treatments.