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. 2020 May 15;6(20):eaba1362. doi: 10.1126/sciadv.aba1362

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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Fig. 1 — (A) Schematic illustration of multistage assembly method for construction of the FeCO-TPP@MSN@HA nanomedicine. (B) Schematic illustration of multistage disassembly strategy and mechanisms for tumor tissue–cell–mitochondria–targeted delivery and controlled release of CO by the FeCO-TPP@MSN@HA nanomedicine. The transmission electron microscopy (TEM) image of the MSN carrier (C); the TEM (D), high angle annular dark field (HADDF) (E), scanning electron microscopy (SEM) (F), and element mapping (G) images of the FeCO-TPP@MSN@HA nanomedicine; the zeta potentials (H), dynamic light scattering (DLS) particle size distributions (I), and FTIR spectra (J) of MSN, FeCO-TPP@MSN, and FeCO-TPP@MSN@HA are shown. a.u., arbitrary units.