Skip to main content
. 2020 May 4;9:e56655. doi: 10.7554/eLife.56655

Figure 6. PKD2 channels contribute to intravascular flow-mediated SK/IK channel activation and vasodilation.

Figure 6.

(A) Representative traces illustrating responses to flow (15 dyn/cm2) and flow (15 dyn/cm2) + ACh (10 µM) in the presence and absence of apamin/Tram-34 (300 nM of each) in pressurized (80 mmHg) mesenteric arteries from Pkd2fl/fl and Pkd2 ecKO mice. (B) Representative traces illustrating responses to apamin/Tram-34 (300 nM of each) in the absence of intravascular flow in pressurized (80 mmHg) mesenteric arteries. (C) Mean data (Pkd2fl/fl: flow, n = 5; flow + apamin/Tram-34, n = 5; flow + ACh (10 µM), n = 5; flow + ACh (10 µM) + apamin/Tram-34, n = 5; static + apamin/Tram-34, n = 5. Pkd2 ecKO: flow, n = 5; flow + apamin/Tram-34, n = 5; flow + ACh (10 µM), n = 5; flow + ACh (10 µM) + apamin/Tram-34, n = 4; static + apamin/Tram-34, n = 5). * indicates p<0.05 versus Pkd2fl/fl in the same condition. # indicates p<0.05 for flow + apamin/Tram-34 versus flow in the same genotype. and indicates p<0.05 for flow + ACh versus flow + ACh + apamin/Tram-34 in the same genotype.