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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Cell Rep. 2020 Apr 21;31(3):107525. doi: 10.1016/j.celrep.2020.107525

Figure 5. Age-Related Differential Methylation Associates with Expression Changes of Genes Belonging to Aging Pathways.

Figure 5.

(A) KEGG and Reactome pathways with a higher proportion of DMRs than global average (DMR/protein ratio > 0.08, FDR ≤ 0.1) (see Table S6). Only pathways with at least two DMRs were included. This analysis resulted in 88 pathways summarized using a pathway network with ClueGO for gene similarity calculations based on the entire pathway gene list. Pathways with a kappa score (gene similarity score) of 0.2 or greater are connected. Darker lines represent higher gene similarity scores. Darker node color indicates a higher DMR content.