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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Endocrinology. 2015 Dec 22;157(2):536–547. doi: 10.1210/en.2015-1725

Figure 3. Alterations of glucagon and insulin secretions in STZ-induced diabetic mice.

Figure 3

Glucagon and insulin secretions were investigated from control and STZ-induced diabetic mice after 4 weeks. After an initial 30min-stabilization step, pancreases were perfused successively with 2.8mM, 16.8mM and 2.8mM glucose-Krebs solutions during 15min-periods each. Pancreatic secretions were collected every minute. Glucagon (A) and insulin (B) levels were monitored in samples collected from perfused pancreas of control (black bars) and STZ (white bars) mice. Pancreatic perfusion experiments include 5 mice per group. * indicate statistical significance compared to control. $ significance compared to first 2.8mM incubation period.