Table 1.

Inverse variance meta-analysis of four TYK2 SNPs in seven different cohorts of patients with SSc and healthy controls (7103 patients with SSc and 12 220 controls)

						Inverse variance test
Chr	SNP	Minor/major	Comment	MAF cases	MAF controls	p Value	OR (95% CI)*	Q
19	rs34536443 (P1104A)	C/G	missense Pro >Ala	0.023	0.026	2.28E-03	0.80 (0.69 to 0.92)	0.13
19	rs35018800 (A928V)	A/G	missense Ala >Val	0.004	0.008	1.27E-03	0.59 (0.42 to 0.81)	0.34
19	rs12720356 (I684S)	C/A	missense Ile >Ser	0.067	0.078	2.63E-05	0.83 (0.78 to 0.91)	0.27
19	rs2304256 (V362F)	A/C	missense Val >Phe	0.246	0.279	3.08E-13	0.83 (0.79 to 0.87)	0.69

^*OR for the minor allele.

Chr, chromosome; MAF, minor allele frequency; Q, heterogeneity value; SNP, single-nucleotide polymorphism; SSc, systemic sclerosis.