Table 3.
Conditional logistic regression analysis of four TYK2 SNPs in the overall combined cohort (7103 patients with SSc and 12 220 controls)
| Conditioned to rs2304256, rs35018800, rs12720356 |
Conditioned to rs2304256, rs12720356, rs34536443 |
Conditioned to rs2304256, rs35018800, rs34536443 |
Conditioned to rs34536443, rs12720356 |
Conditioned to rs35018800, rs12720356, rs34536443 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Unconditioned p value | OR | p Value | OR | p Value | OR | p Value | OR | p Value | OR | p Value | OR |
| rs34536443 | 2.28E-03 | 0.80 | 6.94E-04 | 0.76 | NA | NA | NA | NA | NA | NA | NA | NA |
| rs35018800 | 1.27E-03 | 0.59 | NA | NA | 8.60E-04 | 0.56 | NA | NA | 9.39E-04 | 0.57 | NA | NA |
| rs12720356 | 2.63E-05 | 0.83 | NA | NA | NA | NA | 4.70E-04 | 0.84 | NA | NA | NA | NA |
| rs2304256 | 3.08E-13 | 0.83 | NA | NA | NA | NA | NA | NA | 0.091 | 0.94 | 0.270 | 0.97 |
NA, not applicable; SNP, single-nucleotide polymorphism; SSc, systemic sclerosis.