Fig. 4.

Chronic DMPP selectively increases glucose clearance in the BAT and the muscles. (a) Glucose excursion after injection with glucose 18 h after the eighth injection of daily DMPP (10 mg/kg) or vehicle in DIO WT mice. Glucose clearance into the (b) BAT, (c) gastrocnemius (Gastroc) muscle, (d) quadriceps (Quad) muscle, (e) heart, (f) iWAT, and (g) eWAT. All data are presented as mean ± SEM (n = 7). Data in line graph in (a) were assessed by two-way repeated measures ANOVA (time × drug) with a subsequent Bonferroni post hoc test. All other data (b–g) were probed with two-tailed Student’s t tests, comparing the means of vehicle and DMPP. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 for the effect of drug at the indicated time point or, in bar graphs, compared with vehicle