Fig. 2. Correlations between the average gHFI variant burden and somatic mutation burden and age in the TCGA (n = 7468 cases).

a Variant burden in all human genes (n = 19,581 genes) versus age intervals. b Mutation burden in all human genes versus age intervals. c Variant burden in cancer hallmark genes (n = 1558 genes) versus age intervals. d Mutation burden in cancer hallmark genes versus by age intervals. e Correlation between variant burden and mutation burden in cancer hallmark genes across age. Tags a–k indicate age intervals corresponding to ages ≤30 (n = 307), 31–40 (n = 545), 41–45 (n = 405), 46–50 (n = 568), 51–55 (n = 820), 56–60 (n = 1014), 61–65 (n = 1080), 66–70 (n = 958), 71–75 (n = 820), 76–80 (n = 572), and ≥81 (n = 379) years. The y-axes correspond to log₂ transformed variant/mutation burden. Error bars represent standard error.  The r represents Pearson correlation coefficient. Spearman’s Rho test (two-sided) was used to generate the p value to measure the strength of correlation coefficient.