Fig. 3. Correlation between gHFI variant burden in cancer genes in the PCWAG and UKBB.

a Variant burden for 11 age intervals in the PCAWG (n = 1487 cases, the tags a–k correspond to ages ≤30, 31–40, 41–45, 46–50, 51–55, 56–60, 61–65, 66–70, 71–75, 76–80, and ≥81). b Variant burden in eight age intervals in the UKBB (n = 7198 cases, the tags a–h correspond to ages ≤40, 41–45, 46–50, 51–55, 56–60, 61–65, 66–70, and ≥71). The y-axes show the log₂ transformed variant/mutation burden. Error bars represent standard error. The r represents Pearson correlation coefficient. Spearman’s Rho test (two-sided) was used to generate the p-value to measure the strength of correlation coefficient.