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. 2020 May 15;11(5):373. doi: 10.1038/s41419-020-2578-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The schematic diagram depicting the mechanism that SMAD4 protects FZD4 expression and functions: (i) binds to the promoter of FZD4 and initiates FZD4 transcription directly; (ii) functions as a transcription factor for a pig novel lncRNA, SDNOR which further sponges miR-29c and relieves its suppression to FZD4.