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. 2020 May 15;10:8013. doi: 10.1038/s41598-020-64975-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Canonical DNA methylation profiles of the entire transcriptional units. The canonical gene structure is defined by 7 different features, which are displayed on the x-axis. The length of features were normalised and partitioned into equal numbers of bins. Each dot denotes the mean methylation level per bin and lines denote 5-bin moving averages. The green vertical lines indicate the mean locations of transcriptional start sites.