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. 2020 May 15;10:8024. doi: 10.1038/s41598-020-64895-4

Figure 2.

Figure 2

A diagram of M. tuberculosis PPE18 (a) and PPE60 (b) proteins. PPE18 is composed of 391 amino acids, with amino acids 1–180 classified as the N-terminal domain responsible for TLR-2 binding. The PPE60 protein is 393 amino acids in length, with amino acid residues 6–163 being the N-terminal domain, while amino acids 309–389 contained the C-terminal domain. T cell epitope regions were mapped as solid lines. The locations of homoplastic nsSNPs were shown. Asterisks indicate nsSNPs affecting the T cell epitopes and circles represent nsSNPs outside the T cell epitope regions.