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. 2020 May 15;10:8060. doi: 10.1038/s41598-020-64950-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Over-expression of MEGF11 increased the upregulation of chemokines and proinflammatory cytokine gene expression. Following ingenuity pathway analysis (a), the expressions of chemokines including CCL20, CXCL2, CXCL5 and IL-17A in the o/e MEGF11 MDA-MB-231 line (b,c) and MDA-MB-468 cells (d) were analysed by Western blot (n = 5) and quantified using wild type as a control group. The mRNA transcripts of chemokines including CCL20, CXCL2, CXCL5 (e), and cytokines including TNF-α, IL1β, IL-6, IL-8 and COX2 (f) were quantified with real-time PCR. Asterisks indicate a p value <0.05 in o/e MEGF11 TNBC cells compared to the scramble group by Mann-Whitney U or Student’s t test (n = 3–4).