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. 2020 May 15;10:8060. doi: 10.1038/s41598-020-64950-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-17A increased the upregulation of chemokines and proinflammatory cytokine gene expression. After administration of different doses (0, 0.001, 0.1 ng/mL) of IL-17A in cultured media of MDA-MB-231 and MDA-MB-468 cells, chemokines including CCL20, CXCL2, and CXCL5 (a–c) were analysed by Western blot (n = 4). The mRNA transcripts of chemokines (d,e) and proinflammatory cytokines including TNF-α, IL-1β, IL-6, IL-8, and COX2 (f,g) were quantified with real-time PCR (n = 6). Data were analysed with one-way ANOVA, followed by Dunnett’s post hoc test. Asterisks indicate a p value <0.05 compared to the vehicle group.