Table 2.

The relationship between the expression level of lnc HOTAIR and characteristics of newly diagnosed MM

Characteristics	Number (n = 24)	Relative expression of HOTAIR Mean ± SD	P value
Age (years)
< 65	22	3.06 ± 1.43	0.652
≥ 65	2	3.86 ± 2.47
Gender
Male	16	3.13 ± 1.34	0.569
Female	8	3.12 ± 1.82
Ig isotype
IgG	18	3.34 ± 1.49	0.069
IgA	3	1.63 ± 0.64
LC	3	3.37 ± 1.41
Hemoglobin (g/L)
< 100	20	3.33 ± 1.54	0.08
≥ 100	4	2.13 ± 0.33
B2-Micro globulin (mg/L)
< 3.5	8	2.24 ± 0.78	0.087
≥ 3.5	16	3.58 ± 1.56
Albumin (g/L)
< 35	14	3.47 ± 1.46	0.096
≥ 35	10	2.65 ± 1.43
Creatinine (μmol/L)
< 177	15	2.93 ± 1.32	0.640
≥ 177	9	3.45 ± 1.74
Calcium (mmol/L)
< 2.65	15	2.73 ± 1.20	0.215
≥ 2.65	9	3.79 ± 1.72
Myeloma cells in BM (%)a
< 48	12	2.29 ± 0.67	0.006*
≥ 48	12	3.97 ± 1.60
Bone disease
Absent	9	2.78 ± 0.93	0.599
Present	15	3.34 ± 2.83
D–S stage
I	3	2.21 ± 0.36	0.160
II	7	2.53 ± 1.19
III	14	3.62 ± 1.59
ISS stage
I	5	1.85 ± 0.58	0.031*
II	10	3.06 ± 1.17
III	9	3.91 ± 1.69

D-S Durie–Salmon, ISS International Staging System, BM bone marrow, LC light chain, SD standard deviation

*Statistically significant at P < 0.05

^a48% is the mean value of the percentage of myeloma cells in BM of 24 MM patients