Table 1.
Summary of the reported cases in extranodal NK/T cell lymphoma with meningeal involvement and without parenchymal abnormality
| No. | Age (y), sex | Involved locations | CT or MRI scan | Flow cytometric immunophenotypic studies of NK/T lymphoma cells in the CSF | Therapy | Overall survival | |
|---|---|---|---|---|---|---|---|
| Van Gorp [2] | 1 | 46, F | Meningeal, nasal sinuses | Not mentioned | Not mentioned | RT, CHOP, MTX/DAF/Ara-c | 12 m |
| Kim [3] | 1 | 52, M | Meningeal, testicular, skin | MRI negative | Negative | CHOP, intrathecal methotrexate (MTX) | 8 m |
| Papalkar [4] | 1 | 41, F | Meningeal, right posterior orbit, lungs, pancreas, spleen, uterus, left adrenal gland, heart, pericardium | Not mentioned | Not mentioned | Prednisone | 12 d |
| Dunning [5] | 1 | 67, M | Meningeal, adrenal, bone marrow | MRI positive | Positive | Intravenous dexamethasone | N/A |
| Erős [6] | 2 |
75, M 69, F |
Meninges, skin, bone marrow | CT negative | Positive |
(1) CHOP, cytarabine and etoposide. Intrathecal methotrexate, cytarabine, and dexamethasone (2) Hyper-CVAD,vincristine, etoposide, and dexamethasone. Intrathecal methotrexate, cytarabine, and dexamethasone |
13 m 9 m |
| Hildyard [7] | 1 | 66, F | Pial surfaces of the lower spinal cord | MRI positive | Positive | AspaMetDex, ICE | N/A |
| Cai [8] | 1 | 57, F | Meningeal | MRI positive | Positive | Not mentioned | N/A |
| Shimatani [9] | 1 | 54, M | Meningeal, spinal cord, cauda equina | MRI negative | Positive | Prednisolone | 12 m |
| Zuhaimy [10] | 1 | 56, M | Meningeal, right recti muscles, lacrimal gland, optic nerve sinuses, bone marrow | MRI positive | Not mentioned | Not mentioned | 2 m |
| Present case | 1 | 26, M | Meningeal, nasal cavity, skin, bone, lymphonodal | MRI negative | Positive | VDLP, P-GEMOX, RT, intrathecal methotrexate, cytarabine, and dexamethasone | 15 m |