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. 2020 May 15;11:2450. doi: 10.1038/s41467-020-16144-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic of the five co-regulated genes of the GAG cluster found on chromosome 3. The location on the chromosome is is denoted by nucleotide (nt) number. b Cartoon representation of the GAG biosynthesis system based on bioinformatics and previous studies including the two crystal structures of the glycoside hydrolase domains of Sph3 (PDB 5C5G) and Ega3 (PDB 6OJ1). The synthesized polymer is hypothetical in sequence as the GAG polymer is heterogeneous.