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. 2020 May 15;10:8115. doi: 10.1038/s41598-020-65144-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of Serelaxin on spatial function of GMH animals. Open field test, conducted on 27^th day after GMH induction demonstrated that Serelaxin treatment reversed GMH-induced increase of both central locomotion and time (A), spent by animals in the center zone (B). Furthermore, the treatment improved working memory (T-Maze test, 26^th day after GMH), evaluated by monitoring of spontaneous alteration (C) and time, needed for doing a decision (D). * p < 0.05 compared to sham, # p < 0.05 compared to GMH + vehicle, N = 6–8/group. Data are mean ± SEM. ANOVA, Dunnett.