Chronic inflammatory demyelinating polyneuropathy (CIDP) is frequently misdiagnosed.

Of the clinical phenotypes, “atypical” CIDP is most vulnerable to misdiagnosis.

On nerve conduction studies, particular attention to amplitude-dependant slowing, slowing restricted to compressible sites, and mild/moderate slowing in diabetic patients may minimize electrophysiologic interpretive errors.

Adoption of higher age-dependent cerebrospinal fluid (CSF) reference values may improve CSF diagnostic specificity.

Objective metrics of clinical change are strongly encouraged when clinical change is used to support the diagnosis of CIDP or justify ongoing immunotherapy.