Table 3.

Anhydrodemeclocycline at subinhibitory concentrations can partially rescue tetracycline, tigecycline, eravacycline, and omadacycline efficacy against Pseudomonas aeruginosa Pa-3, E. coli DH10B heterologously expressing Tet(X7), Pseudomonas aeruginosa ATCC 27853, and E. coli DH10B with an empty pZE21 vector.

	Pseudomonas aeruginosa Pa-3		Escherichia coli DH10β + tet(X7)		Pseudomonas aeruginosa ATCC 27853		Escherichia coli DH10β + pZE21
Antibiotic	MIC- 0 µg/mL aDem	MIC- 8 µg/mL aDem	MIC- 0 µg/mL aDem	MIC- 8 µg/mL aDem	MIC- 0 µg/mL aDem	MIC- 8 µg/mL aDem	MIC- 0 µg/mL aDem	MIC- 8 µg/mL aDem
Tetracycline	128	32	256	128	32	32	8	4
Tigecycline	64	64	32	2	8	8	1	1
Eravacycline	64	32	8	8	16	16	1	1
Omadacycline	256	256	64	8	128	128	1	1

In total, 8 µg/ml anhydrodemeclocycline is equivalent to 18 µM anhydrodemeclocycline.