Table 3.
Enriched biological pathways linked with the proteins that are changed as a function of gestational age.
| Biological pathways | Count | p-value | p.adjust | Gene Name | |
|---|---|---|---|---|---|
| Cluster 1 | Cluster 2 | ||||
| Neutrophil degranulation | 19 | 0.000 | 0.000 | C3, LTF, SLPI, ALDOA, KRT1, S100A8, S100A9, CTSD, PSAP, CD14, HSPA8, ALAD, MMP9, PRTN3, SERPINB10, COTL1 | SNAP23, NIT2, PYCARD |
| Gluconeogenesis | 4 | 0.000 | 0.002 | ALDOA, ENO1, ENO2, MDH1 | — |
| Regulation of TLR by endogenous ligand | 3 | 0.000 | 0.005 | S100A8, S100A9, CD14 | — |
| Antimicrobial peptides | 5 | 0.000 | 0.005 | LTF, S100A8, S100A9, PRTN3, DCD | — |
| Post-translational protein phosphorylation | 5 | 0.000 | 0.005 | CP, C3, P4HB | KNG1, LGALS1 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 5 | 0.000 | 0.008 | CP, C3, P4HB | KNG1, LGALS1 |
| Platelet degranulation | 5 | 0.000 | 0.008 | ALDOA, PSAP, LGALS3BP | KNG1, ECM1 |
| Formation of the cornified envelope | 5 | 0.000 | 0.008 | KRT1, IVL, KRT9, KRT2, KRT17 | — |
| Response to elevated platelet cytosolic Ca2+ | 5 | 0.000 | 0.008 | ALDOA, PSAP, LGALS3BP | KNG1, ECM1 |
| Glucose metabolism | 4 | 0.001 | 0.016 | ALDOA, ENO1, ENO2, MDH1 | — |
| Antigen processing-Cross presentation | 4 | 0.001 | 0.020 | CD14, CALR | SNAP23, CTSL |
| Interleukin-12 signaling | 3 | 0.001 | 0.025 | P4HB, LCP1, GSTO1 | — |
| Interleukin-12 family signaling | 3 | 0.002 | 0.040 | P4HB, LCP1, GSTO1 | — |
| Keratinization | 5 | 0.003 | 0.042 | KRT1, IVL, KRT9, KRT2, KRT17 | — |
| Collagen degradation | 3 | 0.003 | 0.044 | CTSD, MMP9 | CTSL |