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. 2020 May 15;11(5):377. doi: 10.1038/s41419-020-2565-2

Fig. 2. Effects of the NLRP3 inflammasome on behavioral performance in EAE mice.

Fig. 2

a A schematic illustration of EAE progression. b Clinical scores of C57BL/6 mice treated with PBS or MCC950 on day 19 after EAE induction. c Clinical scores of C57BL/6 mice treated with PBS or MCC950 on day 40 after EAE induction. d The training track of the mice in the Morris water maze test was recorded and analyzed. The escape latency to find the hidden platform during the 6 consecutive days of the training phase (left). Representative paths of the mice during their search for the hidden platform (right). e The time to reach the target during the probe trials. f The number of crossings over the target location during the probe trials. g The swimming speed of the three groups. The mice were first exposed to contextual fear conditioning test (h) and then to the fear expression test 24 h later (i). The data are the mean ± SEM; n = 15, *P < 0.05.