Table 2.

Multivariable Cox proportional hazards models for patients with newly diagnosed LGG

Factor	TCGA (Training) (N = 238)		OBTS (Validation) (N = 98)
	Hazard Ratio	95% CI	P-value	Hazard Ratio	95% CI	P-value
Grade, III vs II	3.646	(1.869, 7.114)	<0.001	1.951	(0.959, 3.967)	0.065
Age at diagnosis	1.044	(1.019, 1.070)	<0.001	1.055	(1.030, 1.081)	<0.001
Sex, male vs female	0.816	(0.483, 1.377)	0.445	0.845	(0.446, 1.601)	0.606
KPS, imputed	0.979	(0.957, 1.001)	0.063	0.968	(0.948, 0.988)	0.002
Molecular subtype, imputed, IDHmut-codel vs IDHwt	0.127	(0.049, 0.329)	<0.001	0.055	(0.015, 0.196)	<0.001
Molecular subtype, imputed, IDHmut-non-codel vs IDHwt	0.208	(0.097, 0.444)	<0.001	0.249	(0.094, 0.661)	0.005

*Adjusts for grade, age at diagnosis, sex, imputed KPS, and imputed molecular subtype.