Fig. 2.

Survival in patients with LC-LM using quantification of cell-free DNA and circulating tumor cells. (A) Patients with 50 or greater CTCs were more than 3 times more likely to die than those with fewer than 50 CTCs (HR for patients with 50 CTCs³: 3.39, 95% CI: 1.01–11.37; P = 0.048). (B) An increased cfDNA concentration was associated with increased risk of death; using the median cutpoint, there was an increased risk of death among those patients with cfDNA concentration equal to or above the median value (HR for patients with cfDNA concentration³ 0.02 ng/mL: 2.58; 95% CI: 0.94–7.05; P = 0.06).