Table 1.
Patient characteristics stratified for absence versus presence of BTRE
| All Patients (n = 799) | No BTRE (n = 573, 71.7%) | Confirmed BTRE (n = 226, 28.3%) | P* | |
|---|---|---|---|---|
| Sex, m/f | 427/372 | 298/275 | 129/97 | 0.284a |
| Age, y, median (range) | 60.5 (20.5–90.1) | 60.9 (20.5–90.1) | 58.4 (26.6–84.9) | 0.004* b |
| Number of BM, median (range) | 2 (1–64) | 2 (1–64) | 1 (1–20) | 0.095b |
| KPS, median (range) | 80 (20–100) | 80 (30–100) | 80 (20–100) | 0.829b |
| Primary tumor, n (%) | ||||
| Unknown | 45 (5.6) | 34 (75.6) | 11 (24.4) | 0.556 a |
| Lung cancer | 332 (41.6) | 225 (67.8) | 107 (32.2) | 0.037 a |
| Melanoma | 143 (17.9) | 105 (73.4) | 38 (26.6) | 0.616 a |
| Breast cancer | 93 (11.6) | 76 (81.7) | 17 (18.3) | 0.023 a |
| Renal cell cancer | 28 (3.5) | 20 (71.4) | 8 (28.6) | 0.973 a |
| Gastrointestinal cancer | 63 (7.9) | 46 (73.0) | 17 (270) | 0.811 a |
| Other | 95 (11.9) | 66 (68.8) | 30 (31.3) | 0.784a |
| Alcohol, n (%) | ||||
| No abuse | 624 (85.5) | 444 (71.5) | 180 (28.5) | Ref. |
| Ongoing abuse (>30 g/d) | 84 (11.5) | 54 (64.3) | 30 (35.7) | 0.420a |
| Former abuse | 22 (3.0) | 16 (72.7) | 6 (27.3) | 0.812a |
| No information | 81 | |||
| First seizure, type, n (%) | ||||
| Focal seizures (intact awareness) | 83 (36.7) | |||
| Focal seizures (impaired awareness) | 21 (9.3) | |||
| Generalized tonic-clonic (onset unknown) | 92 (40.7) | |||
| Generalized non-motor (onset unknown) | 8 (3.5) | |||
| Status epilepticus | 12 (5.3) | |||
| Incomplete file | 10 | |||
| AED prophylaxis, n (%) | ||||
| No primary prophylaxis | 573 (72.7) | 395 (68.9) | 178 (31.1) | Ref. |
| Primary prophylaxis | 150 (19.0) | 104 (69.3) | 46 (30.7) | 0.582 a |
| Perioperative prophylaxis | 65 (8.2) | |||
| Localization of BM, n (%) | ||||
| Deep brain | 8 (2.6) | 8 (100.0) | 0 (0.0) | 0.942a |
| Cerebellum | 64 (21.1) | 57 (89.1) | 7 (10.9) | 0.899a |
| Brain stem | 6 (2.0) | 5 (83.3) | 1 (16.7) | 0.798a |
| Frontal | 110 (36.2) | 62 (56.4) | 48 (43.6) | 0.094a |
| Parietal | 49 (16.1) | 32 (65.3) | 17 (34.7) | 0.809a |
| Occipital | 27 (8.9) | 16 (59.3) | 11 (40.7) | 0.886a |
| Temporal | 39 (12.8) | 32 (82.1) | 7 (17.9) | 0.121a |
| Supratentorial | 226 (74.3) | 142 (62.8) | 84 (37.2) | <0.001 |
| Infratentorial | 78 (25.7) | 70 (89.7) | 8 (10.3) | Ref. |
| Missing information | 61 | |||
| Multiple BM | 434 | |||
| Surgery, n (%) | ||||
| No surgery | 242 (30.3) | 193 (79.8) | 49 (20.2) | Ref. |
| One or more surgeries | 557 (69.7) | 380 (68.2) | 177 (31.8) | 0.001 a |
| File incomplete | 2 | |||
| Extent of resection of supratentorial single BM | ||||
| No surgery | 28 (17.0) | |||
| Biopsy | 1 (0.6) | |||
| Partial resection | 87 (52.7) | |||
| Gross total resection | 49 (29.3) | |||
| No postoperative MRI | 61 | |||
| Treatments administered after BM diagnosis in non-operated patients, n (%) | ||||
| No chemotherapy or RT | 9 (3.8) | |||
| RT only | 103 (43.1) | |||
| Chemotherapy only | 5 (2.1) | |||
| Chemotherapy and radiotherapy | 122 (51.0) | |||
| Incomplete file | 4 | |||
| No radiotherapy | 14 (5.9) | 12 (85.7) | 2 (20.7) | Ref. |
| Radiotherapy | 224 (94.1) | 177 (79.0) | 47 (21.0) | 0.553a |
| No chemotherapy | 114 (47.1) | 91 (79.8) | 23 (20.2) | Ref. |
| Chemotherapy | 128 (52.9) | 101 (78.9) | 27 (21.1) | 0.860a |
| Treatments administered after surgery of BM, n (%) | ||||
| No chemotherapy or RT | 58 (11.0) | |||
| RT only | 216 (41.1) | |||
| Chemotherapy only | 12 (2.3) | |||
| Chemotherapy and radiotherapy | 239 (45.5) | |||
| Incomplete file | 32 | |||
| No radiotherapy | 72 (13.6) | 58 (80.6) | 14 (19.4) | Ref. |
| Radiotherapy | 456 (86.4) | 300 (65.8) | 156 (34.2) | 0.013 |
| No chemotherapy | 296 (53.5) | 218 (73.6) | 78 (26.4) | Ref. |
| Chemotherapy | 257 (46.5) | 158 (61.5) | 99 (38.5) | 0.002 |
+ The results of database screening are shown. The first column depicts the respective characteristics items, with main items in bold letters and subcharacters in normal letters. The second column shows overall values for all patients. Percentages for sub-items reflect their fraction compared with the whole entity of a main item. The third and fourth columns show the fraction of patients without and with seizures, marked with italic letters. Percentages refer to the fraction of patients with or without seizures for each item. RT indicates radiotherapy of the brain.
*Results of statistical testing, indicating P-values. Significant values are highlighted with bold letters; the respective statistical test is indicated with superscript letters: a = chi-square test; b = Mann–Whitney U-test; Ref. = group of patients that served as a reference.