Table 2.
Characteristics of operated BM patients and risk factors for postoperative seizures
| All Operated Patients (N = 557) | No Postoperative Seizures (N = 471, 84.6%) | One or More Postoperative Seizures (N = 86, 15.4%) | P | |
|---|---|---|---|---|
| Sex, m/f | 291/266 | 247/224 | 44/42 | 0.827a |
| Age, y, median (range) | 61.9 (22.9–90.1) | 62.2 (22.9–90.1) | 60.6 (31.7–84.9) | 0.073b |
| Number of BM, median (range) | 1 (1–36) | 1 (1–36) | 1 (1–20) | 0.854b |
| KPS, % (range) | 80 (20–100) | 80 (30–100) | 80 (20–100) | 0.988 |
| Primary tumor, n (%) | 0.479a | |||
| Unknown | 39 (7.4) | 35 (89.7) | 4 (10.3) | 0.342 a |
| Lung cancer | 224 (40.2) | 183 (81.7) | 41 (18.3) | 0.085 a |
| Melanoma | 90 (16.2) | 76 (84.4) | 14 (15.6) | 0.956 a |
| Breast cancer | 64 (11.5) | 56 (87.5) | 8 (12.5) | 0.307 a |
| Renal cell cancer | 23 (4.1) | 22 (95.7) | 1 (4.3) | 0.130 a |
| Gastrointestinal cancer | 53 (7.0) | 47 (88.7) | 6 (11.3) | 0.540 a |
| Other | 64 (11.5) | 52 (81.3) | 12 (18.8) | 0.585 a |
| Number of BM, n (%) | ||||
| Single BM | 239 (43.2) | 203 (84.9) | 36 (15.1) | Ref. |
| Multiple BM | 314 (56.8) | 265 (84.4) | 49 (15.6) | 0.861 a |
| Incomplete file | 1 | |||
| Localization of BM (supratentorial vs infratentorial), n (%) | ||||
| Single supratentorial BM | 198 (75.9) | 160 (80.8)) | 38 (19.2) | 0.012 |
| Single infratentorial BM | 66 (25.0) | 62 (93.9) | 4 (6.1) | Ref. |
| Localization of single supratentorial BM, n (%) | 0.020 a | |||
| Frontal | 94 (47.5) | 80 (85.1) | 14 (14.9) | 0.144a |
| Parietal | 44 (22.2) | 34 (77.3) | 10 (22.7) | 0.500a |
| Occipital | 25 (12.6) | 16 (64.0) | 9(36.0) | 0.027 a |
| Temporal | 33 (17.2) | 30 (88.2) | 4 (11.8) | 0.022a |
| Depth of single supratentorial BM, n (%) | ||||
| Cortical or subcortical | 175 (88.8) | 144 (82.3) | 31 (17.7) | 0.114a |
| Other | 22 (11.2) | 15 (68.2) | 7 (31.8) | Ref. |
| Number of surgeries, n (%) | 0.039 b | |||
| One brain surgery | 456 (81.9) | 401 (87.9) | 55 (12.1) | Ref. |
| Two or more brain surgeries | 101 (18.1) | 70 (69.3) | 31 (30.7) | <0.001 b |
| Cerebral venous thrombosis, n (%) | ||||
| No | 547 (98.3) | 465 (84.7)) | 82 (15.3) | Ref. |
| Yes | 10 (1.7) | 6 (60.0) | 4 (40.0) | 0.030 |
| Extent of resection of supratentorial single BM, n (%) | 0.011 | |||
| Biopsy | 2 (1.4) | 1 (100.0) | 0 (0) | Ref. |
| Partial resection | 87 (63.0) | 63 (72.4) | 24 (27.6) | |
| Gross total resection | 49 (35.5) | 45 (91.8) | 4 (8.2) | 0.008 |
+ The first column depicts the respective characteristics items, with main items in bold letters and sub-items in normal letters. The second column shows overall values for all patients. Percentages for sub-items reflect their fraction. The third and fourth columns show the fraction of patients without and with seizures. Percentages refer to the fraction of patients with or without seizures for each item.* Results of statistical testing, indicating P-values. Significant values are highlighted with bold letters; the respective statistical test is indicated with superscript letters. a = chi-square test; b = Mann–Whitney U-test; Ref. = group of patients that served as a reference.