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Most Rare Disease Genes are Evolutionarily Ancient
We use the lists of genes associated with childhood diseases (pooled HP:0410280, HP:0030674, HP:0003577, and HP:0003623) and adult genetic diseases (HP:0003581) and analyzed them with the CLIME engine to determine the presence of orthologues and paralogues across species (Li et al., 2014). The presence of paralogues or orthologues is marked by blue cells in the heatmap.
