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. 2020 May 15;13(7):100776. doi: 10.1016/j.tranon.2020.100776

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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PAICS knockdown suppressed invasion and motility of PDAC cells. (A) Representative images of PDAC cells with PAICS knockdown showing less invasion through Transwell Matrigel membranes compared to cells treated with NT shRNA. (B) Representative images showing wound healing assays of PANC-1 and S2VP10 cells lacking PAICS. Images were taken at 0 and 24 hours. Scale bar- 1000 μm. Comparative analysis of wound healing after PAICS knockdown. Asterisk (*) represents statistically significant difference. (C) PDAC cells with reduced PAICS formed smaller spheroids compared with cells treated with NT shRNA as shown by phase-contrast microscopy and GFP (due to the presence of pGreenPuro shRNA expression lentivector for GFP) images. Scale bar- 1000 μm. Histographs showed the spheroid formation capacity of PAICS shRNA relative to NT shRNA (*P < .05).