Table V.

Common gene ontology terms and pathways identified by comparing the gene ontology and pathway enrichment analysis results of transcriptome-wide association studies and messenger RNA expression profiles for knee osteoarthritis.

Category	Tissue	Name	PTWAS*	PmRNA†
GO	Skeletal muscle	GO:0005515~protein binding	< 0.001	< 0.001
	Blood	GO:0005515~protein binding	< 0.001	< 0.001
		GO:0005737~cytoplasm	< 0.001	0.005
		GO:0070062~extracellular exosome	0.002	< 0.001
		GO:0015629~actin cytoskeleton	0.014	0.026
		GO:0006468~protein phosphorylation	0.017	0.033
		GO:0060333~interferon-gamma-mediated signalling pathway	0.017	0.047
		GO:0046982~protein heterodimerization activity	0.033	0.025
Pathway	Skeletal muscle	hsa04610:Complement and coagulation cascades	0.017	0.001
	Blood	hsa05416:Viral myocarditis	0.009	0.050

^*Each PTWAS value was calculated by gene ontology and pathway analysis using DAVID for the significant genes identified by transcriptome-wide association study analysis.

^†Each PmRNA value was calculated by gene ontology and pathway analysis using DAVID for the significant genes identified by messenger RNA expression profiles.

GO, gene ontology; mRNA, messenger RNA; TWAS, transcriptome-wide association study.