Table I.
MicroRNAs targeting histone deacetylase 4.
| microRNA | Function | References |
|---|---|---|
| miRNA-1 | Promoting the differentiation of duck myoblasts; blunting cardiomyocyte hypertrophy elicited by thyroid hormone; regulating chondrocyte phenotype. | 54,55,74 |
| miRNA-133 | Affecting SRF and TGFBR1 expression to promote proliferation of duck myoblasts. | 54 |
| miRNA-365 | Ameliorating dexamethasone-induced suppression of osteogenesis, stimulating chondrocyte differentiation. | 56,75 |
| miRNA-206 | Attenuating denervation-induced skeletal muscle atrophy represses hypertrophy of myogenic cells. | 57,58 |
| miRNA-206-3p | Alleviating chronic constriction injury-induced neuropathic pain. | 59 |
| miRNA-22 | Promoting Th17 cell differentiation in inflammatory intestinal disease progression. | 60 |
| miRNA-140 | Inhibiting proliferation of osteosarcoma cells. | 61 |
| miRNA-125a-5p | Suppressing breast tumourigenesis. | 62 |
| miRNA-155 | Impairing transcriptional activity of B-cell lymphoma 6 (BCL6). | 63 |
| miRNA-20a-5p | Attenuating allergic inflammation in HMC-1 cells. | 64 |
| miRNA-548ah | Promoting the replication and expression of hepatitis B virus. | 65 |
| miRNA-520b | Restraining cell growth in lung cancer. | 66 |
| miRNA-145-3p | Suppressing proliferation and promotes apoptosis and autophagy of osteosarcoma cell. | 67 |
| miRNA-378a-3p | Promoting differentiation and inhibiting proliferation of myoblasts in skeletal muscle development. | 68 |
| miRNA-381 | Regulating chondrocyte hypertrophy. | 69 |
| miRNA-9 | miR-9 upregulation integrates post-ischemic neuronal survival and regeneration in vitro. | 70 |
| miRNA-483-5p | Regulating HDAC4 mRNA during embryogenesis. | 71 |
| miRNA-29a | Modulates the profibrogenic phenotype of the activated hepatic stellate cells. | 72 |
| miRNA-200a | Downregulation of miR-200a enhances the proliferation and migration of HCC cells. | 73 |
HCC, hepatocellular carcinoma; HDAC4, histone deacetylase 4; HMC, human mast cell; miR, microRNA; mRNA, messenger RNA; SRF, serum response factor; TGFBR1, transforming growth factor beta receptor 1; Th17, T-helper 17 cell.