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Empirical rules for predicting oral availability and toxicity of a compound.
| Properties | Oral Availability |
Toxicity | |
|---|---|---|---|
| Lipinski Rules | Veber Rules | Pfizer 3/75 Rules | |
| MW | 500 | – | – |
| LogP | 5 | – | 3 |
| HBA | 10 | – | – |
| HBD | 5 | – | – |
| TPSA | – | 140 | 75 |
| RB | – | 10 | – |
MW: Molecular weight; LogP: Octanol/water partition coefficient; HBA: Hydrogen bond acceptor; HBD: Hydrogen bond donor; TPSA: Topological polar surface area; RB: Rotatable bond count.
