Fig. 1.

Step-wise performance of prediction models. (A) Weighted average positive predictive value (PPV) across groups for each of the three models as a measure of overall model performance, reflecting the average probability that an outcome label predicted by the model was in fact accurate (relative to 37% chance-level). Note that the clinical-only model includes both clinical and cognitive predictors and that the imaging-only model includes both connectome and connectivity measures. (B) changes in outcome prediction relative to the prevalence of each outcome category in the overall sample, illustrating that outcome prediction improved in a step-wise fashion from the clinical-only to the combined model for good and poor outcome groups, with the steepest improvement in the poor outcome group.