Table 10.

Summary of the gross pathology findings; effect of UA on the thyroid gland, heart, kidney, large intestines, larynx and liver. N.V.L = no visible lesions. Lesions were only found on/in the liver in males that were administered a medium dose of 300 mg/kg/day.

		Male				Female
		Group 1, Control	Group 2, 100 mg/kg/day	Group 3, 300 mg/kg/day	Group 4, 1000 mg/kg/day	Group 1, Control	Group 2, 100 mg/kg/day	Group 3, 300 mg/kg/day	Group 4, 1000 mg/kg/day
	Number of animals	10	10	10	10	10	10	10	10
Gland, thyroid	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Heart	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Kidney	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Large intestine, cecum	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Large intestine, colon	Examined	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Large intestine, rectum	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Larynx	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Liver	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	7	10	10	10	10	10
	Prominent lobular architecture	0	0	2	0	0	0	0	0
	Abnormal appearance	0	0	1	0	0	0	0	0