Table 12.

Summary of the gross pathology findings; effect of UA on the skin, small intestines, spinal cord, spleen, stomach, tail, testis and thymus. N.V.L = no visible lesions. Lesions were found in/on the thymus across all test groups and control groups in both males and females.

		Male				Female
		Group 1, Control	Group 2, 100 mg/kg/day	Group 3, 300 mg/kg/day	Group 4, 1000 mg/kg/day	Group 1, Control	Group 2, 100 mg/kg/day	Group 3, 300 mg/kg/day	Group 4, 1000 mg/kg/day
	Number of animals	10	10	10	10	10	10	10	10
Skin	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
	Thin hair coat
Small intestine, duodenum	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Small intestine, ileum	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Small intestine, jejunum	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Spinal cord	Examined	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Spleen	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Stomach	Submitted	10	10	10	10	10	10	10	10
	N.V.L	10	10	10	10	10	10	10	10
Tail	Submitted	–	–	–	–	0	0	1	0
	Scab	–	–	–	–	–	–	1	–
Testis	Submitted	0	0	2	0	–	–	–	–
	N.V.L	0	0	1	0	–	–	–	–
Thymus	Submitted	10	10	10	10	10	10	10	10
	N.V.L	5	7	7	5	6	10	8	7
	Focus	0	1	0	0	0	0	0	0
	Focus; dark	5	2	3	5	4	0	2	3