Table 2.
Effect of MDESm on carrageenan-induced rat paw oedema.
| Treatment | Dose (mg/kg) | 1 h | 2 h | 3 h | 4 h | 5 h | AUC (mlh) |
|---|---|---|---|---|---|---|---|
| Oedema (ml) | |||||||
| Control (dist. water) | 2 ml/kg | 0.42 ± 0.10 | 0.76 ± 0.074 | 0.82 ± 0.047 | 1.00 ± 0.063 | 0.98 ± 0.058 | 3.490 ± 0.245 |
| Ibuprofen | 100 | 0.16 ± 0.07 (61.9) | 0.28 ± 0.09∗ (63.2) | 0.30 ± 0.12∗ (63.4) | 0.36 ± 0.12∗ (64.0) | 0.33 ± 0.11∗ (66.32) | 1.270 ± 0.345 |
| MDESm | 100 | 0.24 ± 0.02 (42.9) | 0.52 ± 0.09 (31.6) | 0.40 ± 0.14∗ (51.2) | 0.52 ± 0.15∗ (48.0) | 0.42 ± 0.14∗ (57.1) | 1.890 ± 0.392 |
| MDESm | 200 | 0.30 ± 0.09 (28.6) | 0.66 ± 0.11 (13.2) | 0.78 ± 0.14 (4.9) | 0.70 ± 0.13 (30.0) | 0.76 ± 0.12 (22.5) | 2.820 ± 0.396 |
| MDESm | 400 | 0.34 ± 0.07 (19.1) | 0.75 ± 0.15 (1.3) | 0.94 ± 0.06 (−14.6) | 0.98 ± 0.04 (2.0) | 0.92 ± 0.05 (6.1) | 3.480 ± 0.289 |
Mean ± SEM, n = 5; p < 0.05 compared to control (one-way ANOVA; Dunnett's post hoc test); values in parentheses are percentage oedema reduction compared to control. MDESm = methanol-dichloromethane extract of Stemonocoleus micranthus; AUC = area under the curve.