Table 5.

The main pharmacokinetics of 5 compounds in rat plasma (n = 6).

Compounds	Treatment	C max (ng/mL)	T max (h)	T 1/2 (h)	AUC(0–24 h) (ng/L·h)	AUC(0–∞) (ng/L·h)
Geniposidic acid	CGF	1022.83 ± 450.17	3.33 ± 1.63	2.52 ± 0.64	7696.99 ± 2741.28	8586.63 ± 3450.88
	SGF	398.33 ± 107.8∗∗	1.78 ± 0.44∗	2.93 ± 3.45	1730.86 ± 618.74∗∗	1774.38 ± 654.94∗∗
	GCGF	669.63 ± 431.89	3.33 ± 3.43	1.72 ± 0.69∗	2988.13 ± 2302.06∗∗	3250.09 ± 2342∗∗
	GIGF	272.00 ± 164.04∗∗	2.40 ± 1.26	1.50 ± 0.42∗∗	1187.21 ± 813.41∗∗	1351.01 ± 827.12∗∗
Genipin-1-β-gentiobioside	CGF	149.90 ± 132.07	0.55 ± 0.33	0.72 ± 0.25	141.12 ± 104.11	237.29 ± 119.51
	SGF	79.08 ± 39.47	0.61 ± 0.31	0.61 ± 0.18	109.26 ± 58.78	121.03 ± 54.86∗
	GCGF	102.92 ± 58.15	0.78 ± 0.20	0.78 ± 0.32	206.27 ± 142.55	233.30 ± 165.74
	GIGF	62.94 ± 16.81	1.05 ± 0.37∗#	0.91 ± 0.36#	131.30 ± 36.78	151.67 ± 48.73
Geniposide	CGF	1071.67 ± 598.46	1.54 ± 1.30	3.21 ± 2.31	4000.13 ± 1677.19	4119.45 ± 1649.61
	SGF	455.44 ± 160.36∗	0.89 ± 0.72	1.61 ± 0.63	1141.92 ± 389.07∗∗	1200.78 ± 382.09∗∗
	GCGF	581.00 ± 240.71∗	0.86 ± 0.13	1.44 ± 0.53∗	1862.67 ± 1078.69∗∗	1899.73 ± 1092.04∗∗
	GIGF	211.50 ± 109.10∗∗##	1.30 ± 0.48	1.08 ± 0.45∗	733.81 ± 519.14∗∗	781.95 ± 530.75∗∗
Genipin	CGF	76.44 ± 40.93	1.11 ± 0.40	3.42 ± 1.94	265.30 ± 103.43	356.72 ± 139.94
	SGF	98.05 ± 41.84	1.00 ± 0.55	1.39 ± 0.88	233.77 ± 141.78	281.41 ± 178.60
	GCGF	68.52 ± 19.41	1.10 ± 0.52	1.39 ± 0.98	152.67 ± 113.60	329.06 ± 394.68
	GIGF	—	—	—	—	—
Crocetin	CGF	165.02 ± 52.86	7.30 ± 3.93	41.65 ± 57.62	1251.80 ± 354.98	10824.60 ± 13505.86
	SGF	152.51 ± 81.90	6.61 ± 4.05	56.17 ± 42.99	1258.95 ± 596.55	7510.78 ± 8494.79
	GCGF	162.66 ± 76.43	6.43 ± 5.02	12.75 ± 6.64#	1098.06 ± 522.58	3845.62 ± 5252.68
	GIGF	91.18 ± 35.65∗	1.29 ± 2.31∗#	31.84 ± 29.27	621.22 ± 389.71∗#	3610.39 ± 2206.09

CGF as control group, p < 0.05^∗; p < 0.01^∗∗, SGF as control group, p < 0.05^#; p < 0.01^##.