Table 2.
Study endpoints at 6 weeks
| Controls | DOX group | DOX + EMPA group | DOX + FURO group | |
|---|---|---|---|---|
| Weight, g | 23.18 ± 1.8 | 21.45 ± 2.7 | 22.5 ± 2.1 | 21.8 ± 2.4 |
| Glucose, mg/dl | 200.6 ± 40 | 166.6 ± 72 | 205.5 ± 39 | 170.5 ± 50 |
| Systolic pressure, mmHg | 121 ± 15 | 102 ± 37 | 119 ± 20* | 105 ± 33 |
| Diastolic pressure, mmHg | 76 ± 11 | 41 ± 10 | 65 ± 28* | 60 ± 24* |
| LVEF, % | 68.7 ± 5% | 49.24 ± 8 | 61.30 ± 11* | 55.79 ± 11 |
| LVFS, % | 39.4 ± 3% | 24.70 ± 5 | 33.08 ± 8* | 28.62 ± 8 |
| LVEDd, mm | 3.11 ± 0.1 | 3.98 ± 0.4 | 3.89 ± 0.3 | 3.80 ± 0.7 |
| LVESd, mm | 1.93 ± 0.5 | 2.98 ± 0.4 | 2.67 ± 0.5 | 2.73 ± 0.5 |
| IVS, mm | 0.81 ± 0.001 | 0.69 ± 0.004 | 0.77 ± 0.001* | 0.77 ± 0.005* |
| PW, mm | 0.78 ± 0.001 | 0.71 ± 0.005 | 0.76 ± 0.013 | 0.76 ± 0.014 |
| Longitudinal strain (LS),% | − 24.1 ± 4% | − 13.93 ± 5 | − 17.52 ± 3* | − 16.1 ± 3.5 |
| Circumferential strain (CS), % | − 29.9 ± 8% | − 15.91 ± 6 | − 25.75 ± 6* | − 15.8 ± 3.3 |
| Radial strain (RS), % | 46.0 ± 7% | 26.7 ± 13 | 24.0 ± 5 | 26.1 ± 4 |
| E/A | 1.6 ± 0.1 | 1.7 ± 0.2 | 1.6 ± 0.2 | 1.5 ± 0.1 |
| E/Eʹ | 41.1 ± 2.2 | 77.3 ± 3.5 | 61.1 ± 5.7* | 59.4 ± 4* |
Values are mean ± SD, or n (%)
LVEF left ventricular ejection fraction, LVFS left ventricular fractional shortening, IVS interventricular septum, PW posterior wall
*p < 0.05 compared to DOX