Table 2.
Averaged hemodynamic and metabolic parameters during the study period in the overall population
| Study period | Day 1–2 | Day 3–4 | Day 5–7 | |
|---|---|---|---|---|
| Natremia (mmol/L) | 142 [139–144] | 142 [140–146] | 143 [140–147] | 140 [138–143] *,† |
| Hyponatremia (Na ≤ 135 mmol/) | 16 (27) | 0 (0) | 5 (8) | 11 (18) * |
| Fluid intake (L/24 h) | 3.2 [2.8–3.6] | 3.3 [2.9–3.8] | 3.2 [2.7–3.7] | 3.2 [2.5–3.7] * |
| Diuresis (L/24 h) | 2.2 [1.9–2.8] | 1.8 [1.3–2.5] | 2.2 [1.6–2.9] | 2.4 [1.8–2.9] * |
| Fluid balance (L/24 h) | 0.8 [0.6–1.2] | 1.4 [0.4–2.0] | 1.0 [0.4–1.4] | 0.6 [− 0.1–1.1] * |
| Sodium intake (mmol/24 h) | 323 [277–378] | 363 [299–432] | 295 [234–371] | 302 [229–365] * |
| Urinary sodium excretion (mmol/24 h) | 284 [221–362] | 132 [91–275] | 309 [187–422] | 310 [226–409] * |
| Sodium balance (mmol/24 h) | 47 [− 33–104] | 215 [84–293] | 16 [− 115–106] | 22 [− 85–90] * |
| 24-h CLCR(ml/min/1.73m2) | 143 [116–160] | 136 [96–154] | 143 [110–165] | 147 [115–166] * |
| Augmented renal clearance | 32 (53) | 33 (55) | 34 (57) | 33 (55) |
| Urinary osmolality (mmol/L) | 569 [503–653] | 498 [423–627] | 590 [487–655] | 603 [510–700] * |
| 24-h CLH2O(ml/min/1.73m2) | −1.3 [− 1.5 – − 1.0] | − 0.8 [− 1.2 – − 0.4] | − 1.3 [− 1.6 – − 0.8] | − 1.6 [− 2.1 – − 1.1] *,† |
| Fractional excretion of sodium (%) | 0.94 [0.76–1.21] | 0.56 [0.33–1.15] | 0.98 [0.70–1.40] | 0.94 [0.72–1.31] * |
| Fractional excretion of urate (%) | 19 [12–22] | 13 [11–18] | 16 [12–21] | 22 [13–28] *,† |
| Mean MAP | 92 [87–96] | 87 [83–92] | 91 [85–97] | 93 [88–100] * |
| Use of vasopressor | 54 (90) | 54 (90) | 42 (70) | 30 (50) * |
Data expressed as median [interquartile 25–75] and numbers (percentages)
* = p < 0.05 between period 1 and period 3; † = p < 0.05 between period 2 and period 3 (continuous variables compared using Wilcoxon test for paired samples)