Table 3.
Evolution of hemodynamic and metabolic parameters in patients who presented a first episode of hyponatremia over the study period (N = 16)
| Day of hyponatremia | Day - 1 | Day - 2 | |
|---|---|---|---|
| Natremia (mmol/L) | 135 [134–135] | 138 [137–139] | 141 [139–144] *,† |
| Fluid intake (L/24 h) | 3.0 [2.5–3.3] | 2.5 [2.3–3.0] | 2.7 [2.6–3.0] |
| Diuresis (L/24 h) | 2.2 [2.0–3.1] | 2.3 [1.7–3.2] | 2.2 [1.9–2.6] |
| Fluid balance (L/24 h) | 0.6 [− 0.1–1.0] | 0.5 [− 0.8–0.9] | 0.4 [−0.2–1.0] |
| Sodium intake (mmol/24 h) | 356 [297–425] | 278 [224–363] | 288 [252–319] * |
| Urinary sodium excretion (mmol/24 h) | 316 [178–452] | 372 [288–553] | 403 [297–466] |
| Sodium balance (mmol/24 h) | 87 [− 97–148] | − 98 [− 211–74] | −130 [− 213 – − 2] |
| 24-h CLCR(ml/min/1.73m2) | 145 [127–165] | 161 [139–173] | 141 [128–163] |
| Urinary osmolality (mmol/L) | 595 [491–686] | 551 [498–712] | 636 [483–740] |
| 24-h CLH2O(ml/min/1.73m2) | - 1.6 [−1.9 – − 1.3] | - 1.6 [− 1.9 – − 1.3] | - 1.8 [− 2.0 – − 1.1] |
| Fractional excretion of sodium (%) | 1.04 [0.52–1.80] | 0.95 [0.81–2.27] | 1.15 [0.99–1.63] |
| Fractional excretion of urate (%) | 27 [15–28] | 21 [14–27] | 23 [16–25] * |
| BUN (mmol/L) | 4.9 [3.3–6.3] | 4.1 [2.5–5.2] | 3.0 [2.3–4.6] * |
| Protidemia (g/L) | 65 [60–67] | 62 [58–68] | 58 [53–63] *,† |
| Hte (%) | 32 [29–36] | 33 [30–35] | 31 [30–35] † |
| Mean MAP (mmHg) | 92 [86–98] | 94 [91–94] | 91 [87–94] |
| Use of vasopressor | 5 (31) | 8 (50) | 8 (50) |
Data expressed as median [interquartile 25–75] and numbers (percentages)
* = p < 0.05 between Day − 2 and Day 0; † = p < 0.05 between Day − 2 and Day − 1 (continuous variables compared using Wilcoxon test for paired samples)