Table 3.
Results of the meta-analysis on HTRA1 rs11200638 polymorphism and AMD risk in total and types of subgroups
| Variables | N | Case/ | A-allele vs. G-allele | AG vs. GG | AA+AG vs. GG | AA vs. GG | AA vs. AG + GG |
|---|---|---|---|---|---|---|---|
| Control | OR(95%CI) PhP | OR(95%CI) PhP | OR(95%CI) PhP | OR(95%CI) PhP | OR(95%CI) PhP | ||
| Total | 38 | 8582/7452 | 2.39(2.12–2.69)0.000 0.000 | 1.91(1.69–2.16)0.000 0.000 | 2.63(2.30–3.01)0.000 0.000 | 5.45(4.26–6.98)0.000 0.000 | 3.75(3.04–4.63)0.000 0.000 |
| HWE | 33 | 8101/7215 | 2.56(2.34–2.80)0.000 0.000 | 1.98(1.76–2.23)0.001 0.000 | 2.80(2.49–3.15)0.000 0.000 | 6.13(5.09–7.38)0.000 0.000 | 4.10(3.55–4.73)0.000 0.000 |
| Ethnicity | |||||||
| Asian | 19 | 3424/4004 | 2.51(2.22–2.83)0.000 0.000 | 1.67(1.47–1.88)0.167 0.000 | 2.68(2.25–3.19)0.009 0.000 | 5.36(4.31–6.66)0.003 0.000 | 3.70(3.16–4.35)0.009 0.000 |
| Caucasian | 14 | 4677/3211 | 2.63(2.29–3.02)0.000 0.000 | 2.37(2.15–2.61)0.140 0.000 | 2.94(2.51–3.45)0.004 0.000 | 7.52(5.62–10.07)0.014 0.000 | 5.00 (3.91–6.40)0.070 0.000 |
| SOC | |||||||
| HB | 22 | 3589/3273 | 2.56(2.28–2.88)0.000 0.000 | 1.86(1.58–2.19)0.025 0.000 | 2.81(2.38–3.31)0.005 0.000 | 5.99(4.74–7.59)0.001 0.000 | 3.93(3.31–4.68)0.005 0.000 |
| PB | 11 | 4512/33942 | 2.55(2.18–2.99)0.000 0.000 | 2.16(1.84–2.53)0.021 0.000 | 2.80(2.35–3.35)0.001 0.000 | 6.37(4.64–8.76)0.001 0.000 | 4.43(3.41–5.75)0.009 0.000 |
| AMD type | |||||||
| Wet | 17 | 3476/3579 | 3.03(2.59–3.55)0.000 0.000 | 2.11(1.81–2.46)0.138 0.000 | 3.40(2.90–3.99)0.073 0.000 | 7.65(5.73–10.21)0.009 0.000 | 4.65(3.72–5.82)0.008 0.000 |
| Dry | 5 | 462/848 | 2.36(1.71–3.24)0.750 0.000 | 1.33(0.76–2.32)0.705 0.316 | 2.08(1.24–3.48)0.618 0.005 | 6.01(3.05–11.87)0.889 0.000 | 4.77(2.79–8.16)0.964 0.000 |
| Genotyping | |||||||
| Others | 5 | 3004/2599 | 2.55(2.22–2.94)0.027 0.000 | 2.14(1.67–2.73)0.006 0.000 | 2.85(2.38–3.43)0.055 0.000 | 6.25(4.26–9.15)0.005 0.000 | 4.18 (3.14–5.57)0.033 0.000 |
| Sequencing | 14 | 2613/2332 | 2.84(2.61–3.09)0.237 0.000 | 2.08(1.81–2.41)0.252 0.000 | 3.19(2.79–3.65)0.710 0.000 | 7.00(5.84–8.39)0.677 0.000 | 4.51(3.90–5.21)0.169 0.000 |
| TaqMan | 4 | 591/524 | 2.66(1.43–4.94)0.000 0.002 | 2.79(1.31–5.91)0.000 0.008 | 3.61(1.52–8.60)0.000 0.004 | 7.52(2.05–27.68)0.000 0.002 | 3.86(1.66–8.98)0.002 0.002 |
| PCR-RFLP | 6 | 1037/1121 | 1.98(1.72–2.26)0.105 0.000 | 1.76(1.45–2.14)0.611 0.000 | 2.08(1.73–2.50)0.411 0.000 | 4.30(2.51–7.35)0.073 0.000 | 3.33(2.09–5.31)0.095 0.000 |
| RT-PCR | 2 | 509/293 | 2.91(2.30–3.69)0.755 0.000 | 2.08(1.51–2.86)0.643 0.000 | 2.90(2.15–3.92)0.734 0.000 | 9.83(5.18–18.65)0.817 0.000 | 7.19(3.84–13.45)0.806 0.000 |
| MassARRAY MALDI-TOF | 2 | 347/346 | 2.18(1.39–3.49)0.043 0.001 | 1.46(0.95–2.24)0.213 0.088 | 2.22(1.13–4.38)0.099 0.021 | 3.84(1.53–9.63)0.044 0.004 | 3.05(1.78–5.23)0.097 0.000 |
Ph: value of Q-test for heterogeneity test; P: Z-test for the statistical significance of the OR