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. 2020 May 15;20:170. doi: 10.1186/s12935-020-01251-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Dose-response curves for parental (CEM), vincristine-resistant (CEM-VCR R) and 2ME2-resistant (CEM/2ME2-28.8R) ALL cell lines treated with varying concentrations of commercial drugs (a–e) or N-alkylisatins (f–h). CEM (black), CEM-VCR R (solid) and CEM-2ME2/28.8R (dashed) cells were incubated with increasing concentrations of drug at 37 °C for 48 h. Cells were then assessed for metabolic activity by addition of MTS reagent and the OD measured at 490 nm. Dose–response curves were generated using GraphPad Prism v7.0. Values are the mean of triplicates (± SD)