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Displacement of MTC from the colchicine-binding site by a HMB-isatin, b I4M-isatin and c N1M-isatin. MTC fractional saturation values were calculated based on the concentration of MTC binding sites (0.8 per tubulin dimer) and the MTC binding constant (4.7 × 105 M−1). Solid line is the best fit to a single site competition model as calculated by EQUIGRA5. Values are the mean of triplicates ± SEM
