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Binding affinity values for HMB-isatin, I4M-isatin and N1M-isatin compared with reference compounds of the colchicine site
| Compound | Binding affinity (M−1) ± SEMa |
|---|---|
| Colchicine | 1.16 × 107 (37 °C) [70] |
| Podophyllotoxin | 1.8 × 106 [71] |
| MTC | 4.7 × 105 [72] |
| HMB-isatin | 2.7 ± 1.1 × 105 |
| I4M-isatin | 3.4 ± 1.5 × 105 |
| N1M-isatin | 1.4 ± 0.2 × 105(× 104) |
aValues (Kb) are the mean of three independent experiments performed in triplicate (n = 9) ± SEM
