Fig. 1.

Human AH outflow pathways. (A) Diagram of the anterior segment of the human eye, which includes the cornea, iris, ciliary body (CB), and lens. AH is secreted by the CB and circulates (blue arrows) within the anterior chamber prior to draining from the eye through one of two pathways located within the iridocorneal angle delineated by boxed area. (B) Enlarged view of the iridocorneal angle (boxed area in A) highlighting two outflow pathways for AH. In the conventional pathway, AH traverses the TM, first through the uveal meshwork (orange highlight), then the corneoscleral meshwork (light green highlight), and finally, the JCT (dark green highlight) prior to entering SC. AH exits the SC via CCs that empty into aqueous veins (AVs) that themselves merge with episcleral veins (EVs). Nonfiltering TM is located at the insert region (yellow highlight), referred to as Schwalbe line (SL), which abuts the corneal endothelium. In the uveoscleral pathway, AH exits via the interstices of the CM. SS, scleral spur.