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. Author manuscript; available in PMC: 2020 May 16.
Published in final edited form as: J Leukoc Biol. 2020 Feb 4;107(4):663–671. doi: 10.1002/JLB.3A0120-379RR

FIGURE 6. p38 MAPK inhibition abrogates IL-33-enhancement of IL-12-induced activity.

FIGURE 6

(A) IFN-γ production (pooled results of 4 independent subjects) by human NK cells following 150 min pretreatment with vehicle (0.1% DMSO) or various concentrations of R-1503 (0–500 nM) and subsequent stimulation with IL-12 and IL-33 (doses listed in ng/ml). Shaded bars reflect administration of >1 cytokine. (B and C) Effect of pretreatment with 125 nM R-1503 on levels of IFN-γ and TNF in cell-free supernatant collected 6 h after cytokine stimulation. Each dot represents the mean of 3 biological replicates of an independent subject (n = 5). Multiple comparisons of ordinary 1-way ANOVA were used to compare groups with P < 0.1 shown