Table 4.

Analysis of clinical symptoms observed in patients with COVID-19, stratified by date of initial diagnosis*

Clinical symptom	No. of studies	No. of patients	Heterogeneity		Model	Meta-analysis
			P value	I2 (%)		R (95% CI)	P value
Fever
Group 1	51	8473	<0.001	95.9	Random	0.784 (0.736 to 0.828)	<0.001
Group 2	14	2162	<0.001	97.9	Random	0.813 (0.667 to 0.924)	<0.001
Fatigue
Group 1	45	7848	<0.001	96.9	Random	0.340 (0.277 to 0.405)	<0.001
Group 2	11	1971	<0.001	93.9	Random	0.366 (0.268 to 0.470)	<0.001
Cough							<0.001
Group 1	52	8539	<0.001	97.2	Random	0.583 (0.515 to 0.649)	<0.001
Group 2	14	2162	<0.001	86.6	Random	0.640 (0.574 to 0.703)	<0.001
Myalgia							<0.001
Group 1	37	5625	<0.001	93.0	Random	0.219 (0.177 to 0.264)	<0.001
Group 2	10	1938	<0.001	91.7	Random	0.271 (0.193 to 0.358)	<0.001

*Group 1: all patients; group 2: diagnosed before 31 January 2020.